Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection

被引：121

作者：

Thompson, George R., III ^{[1
]}

Wiederhold, Nathan P. ^{[1
,3
,4
]}

Vallor, Ana C. ^{[1
]}

Villareal, Nyria C. ^{[1
]}

Lewis, James S., II ^{[1
,2
]}

Patterson, Thomas F. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Internal Med, Div Infect Dis, San Antonio, TX 78229 USA

[2] Univ Hlth Syst, Dept Pharm, San Antonio, TX 78229 USA

[3] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78299 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 10期

关键词：

D O I：

10.1128/AAC.00473-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.

引用

页码：3783 / 3785

页数：3

共 25 条

[1] Identification of Candida spp. by randomly amplified polymorphic DNA analysis and differentiation between Candida albicans and Candida dubliniensis by direct PCR methods [J].

Bautista-Muñoz, C ;

Boldo, XM ;

Villa-Tanaca, L ;

Hernández-Rodríguez, C .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (01) :414-420

[2] Molecular genotyping of Candida species with special respect to Candida (Torulopsis) glabrata strains by arbitrarily primed PCR [J].

Becker, K ;

Badehorn, D ;

Deiwick, S ;

Peters, G ;

Fegeler, W .

JOURNAL OF MEDICAL MICROBIOLOGY, 2000, 49 (06) :575-581

[3] Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during Candidemia treatment [J].

Cleary, John D. ;

Garcia-Effron, Guillermo ;

Chapman, Stanley W. ;

Perlin, David S. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (06) :2263-2265

[4] In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility [J].

Cota, Jason ;

Carden, Michael ;

Graybill, John R. ;

Najvar, Laura K. ;

Burgess, David S. ;

Wiederhold, Nathan P. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (11) :3926-3928

[5] Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors [J].

Douglas, CM ;

DIppolito, JA ;

Shei, GJ ;

Meinz, M ;

Onishi, J ;

Marrinan, JA ;

Li, W ;

Abruzzo, GK ;

Flattery, A ;

Bartizal, K ;

Mitchell, A ;

Kurtz, MB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) :2471-2479

[6] A SACCHAROMYCES-CEREVISIAE MUTANT WITH ECHINOCANDIN-RESISTANT 1,3-BETA-D-GLUCAN SYNTHASE [J].

DOUGLAS, CM ;

MARRINAN, JA ;

LI, W ;

KURTZ, MB .

JOURNAL OF BACTERIOLOGY, 1994, 176 (18) :5686-5696

[7] Caspofungin resistance in Candida albicans:: Correlating clinical outcome with laboratory susceptibility testing of three is genic isolates serially obtained from a patient with progressive candida esophagitis [J].

Hernandez, S ;

López-Ribot, JL ;

Najvar, LK ;

McCarthy, DI ;

Bocanegra, R ;

Graybill, JR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (04) :1382-1383

[8] Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase [J].

Kahn, Jennifer Nielsen ;

Garcia-Effron, Guillermo ;

Hsu, Ming-Jo ;

Park, Steven ;

Marr, Kieren A. ;

Perlin, David S. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (05) :1876-1878

[9] Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility [J].

Katiyar, Santosh ;

Pfaller, Michael ;

Edlind, Thomas .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (08) :2892-2894

[10] Amphotericin B and caspofungin resistance in Candida glabrata isolates recovered from a critically ill patient [J].

Krogh-Madsen, M ;

Arendrup, MC ;

Heslet, L ;

Knudsen, JD .

CLINICAL INFECTIOUS DISEASES, 2006, 42 (07) :938-944

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