The Tol proteins of Escherichia coli and their involvement in the uptake of biomolecules and outer membrane stability

被引：106

作者：

Lazzaroni, JC ^{[1
]}

Germon, P ^{[1
]}

Ray, MC ^{[1
]}

Vianney, A ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS,UMR 5577, INSA, Unite Microbiol & Genet, F-69622 Villeurbanne, France

来源：

FEMS MICROBIOLOGY LETTERS | 1999年 / 177卷 / 02期

关键词：

TolQ; TolR; TolA; TolB; Pal; outer membrane stability; periplasm; uptake of macromolecule;

D O I：

10.1016/S0378-1097(99)00293-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Tol proteins of Escherichia coli are involved in outer membrane stability. They are also required for the uptake of the group A colicins and the translocation of filamentous phage DNA into the cytoplasm. The tol-pal genes constitute two operons in the E. coli genome, orf1tolQRA and tolBpalorf2. The TolQ TolR TolA proteins form a complex in the cytoplasmic membrane, while TolB and Pal interact near the outer membrane. Most of the amino acid residues of TolA, TolB, TolR and Pal are localized in the periplasm. Recent advances in the knowledge of interactions of Tol-Pal proteins with other envelope components, or with group A colicins, are presented, together with current hypotheses about the role of the Tol proteins in outer membrane stability. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：191 / 197

页数：7

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