Development of a solvent selection guide for aldehyde-based direct reductive amination processes

被引：63

作者：

McGonagle, Fiona I. ^{[1
]}

MacMillan, Donna S. ^{[1
]}

Murray, Jane ^{[2
]}

Sneddon, Helen F. ^{[3
]}

Jamieson, Craig ^{[1
]}

Watson, Allan J. B. ^{[1
]}

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland

[2] Sigma Aldrich, Old Brickyard, Gillingham SP8 4XT, Dorset, England

[3] GlaxoSmithKline, Med Res Ctr, Green Chem Performance Unit, Stevenage SG1 2NY, Herts, England

来源：

GREEN CHEMISTRY | 2013年 / 15卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

BOROHYDRIDE EXCHANGE RESIN; TITANIUM(IV) ISOPROPOXIDE; REDUCING AGENT; MEDICINAL CHEMISTS; GREEN PROCESS; KETONES; EFFICIENT; BORANE; DICHLOROMETHANE; HYDROGENATION;

D O I：

10.1039/c3gc40359a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

引用

页码：1159 / 1165

页数：7

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