NT-3 has a tropic effect on process outgrowth by postnatal auditory neurones in vitro

被引：28

作者：

Malgrange, B

Lefebvre, PP

Martin, D

Staecker, H

VandeWater, TR

Moonen, G

机构：

[1] UNIV LIEGE,HUMAN PHYSIOL & PATHOPHYSIOL,B-4020 LIEGE,BELGIUM

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OTOLARYNGOL,BRONX,NY 10461

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

来源：

NEUROREPORT | 1996年 / 7卷 / 15-17期

关键词：

auditory neurones; chemotropism; cochlea; growth factor therapy; neurotrophin-3;

D O I：

10.1097/00001756-199611040-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing.

引用

页码：2495 / 2499

页数：5

共 24 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR AND NEUROTROPHIN-3 SUPPORT THE SURVIVAL AND NEURITOGENESIS RESPONSE OF DEVELOPING COCHLEOVESTIBULAR GANGLION NEURONS [J].