Evaluation of three commercial enzyme-linked immunosorbent assay kits for diagnosis of Helicobacter pylori in Chinese patients

被引：47

作者：

Leung, WK

Ng, EKW

Chan, FKL ^{[1
]}

Chung, SCS

Sung, JJY

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, NT, Peoples R China

[2] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, NT, Peoples R China

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1999年 / 34卷 / 01期

关键词：

D O I：

10.1016/S0732-8893(99)00002-4

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Most of the commercial serological assays for H. pylori nle developed and validated in western countries. We evaluated the accuracy of three popular commercial ELISA tests for H. pylori in the Chinese population. Eighty dyspeptic patients were recruited and diagnosis of H. pylori infection was based on biopsy urease lest, histology and urea breath test. Thirty-six patients (45%) were positive for H. pylori infection by two ol more positive reference tests. Anti-H. pylori IgG antibody was detected by three commercial ELISA tests: GAP Ige (Bio-Rad), HM-CAP (Enteric Products) and Pyloriset EIA-G (Orion). The respective sensitivity, specificity, positive and negative predictive values of the three tests were: GAP IgG (50%, 97.4%, 93.8%, 71.7%), HM-CAP (72.7%, 68.4%, 66.7%, 74.3%) and Pyloriset EIA-G (75%, 86.4%, 81.8%, 80.9%). Despite the high accuracy reported in the West, the performance of these commercial serological tests rc,iis unsatisfactory when used in Chinese patients. (C) 1999 Elsevier Science Inc.

引用

页码：13 / 17

页数：5

共 22 条

[21] Comparison of three commercially available enzyme-linked immunosorbent assays and biopsy-dependent diagnosis for detecting Helicobacter pylori infection [J].