Effects of interleukin-13 on antifungal activity of human monocytes against Candida albicans

被引：8

作者：

Katsifa, H

Tsaparidou, S

Diza, E

Gil-Lamaignere, C

Walsh, TJ

Roilides, E ^{[1
]}

机构：

[1] Aristotelian Univ Thessaloniki, Hippokrat Hosp, Dept Pediat 3, GR-54642 Thessaloniki, Greece

[2] Aristotelian Univ Thessaloniki, Dept Microbiol, GR-54006 Thessaloniki, Greece

[3] NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2001年 / 31卷 / 03期

关键词：

interleukin-13; monocyte; Candida albicans;

D O I：

10.1111/j.1574-695X.2001.tb00522.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the effects of human interleukin-13 (IL-13) on human monocytes' (MNC) activities against Candida albicans, an important human pathogen. Increased phagocytosis of blastoconidia was observed after incubation with 50 U ml(-1) of IL-13 for 4 h or 48 h in the presence or absence of serum. The latter effect was inhibited by anti-IL-13 monoclonal antibody or mannose. Incubation of MNC with 50 U ml(-1) or IL-13 for 2 h significantly enhanced superoxide anion production in response to phorbol myristate acetate. IL-13 did not, however, alter the damage caused by MNC to hyphae, whereas it suppressed killing of blastoconidia. IL-13 has variable effects on MNC activities and may play an important immunoregulatory role against C albicans. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science BN. All rights reserved.

引用

页码：211 / 217

页数：7

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[11] A RAPID COLORIMETRIC ASSAY OF FUNGAL VIABILITY WITH THE TETRAZOLIUM SALT MTT [J].