Bidirectional and convergent routes to oligo(tetrahydrofurans)

被引：41

作者：

Koert, U ^{[1
]}

Stein, M ^{[1
]}

Wagner, H ^{[1
]}

机构：

[1] HUMBOLDT UNIV BERLIN,INST CHEM,D-10115 BERLIN,GERMANY

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 1997年 / 3卷 / 07期

关键词：

oligomers; polyethers; tetrahydrofurans; Williamson reaction;

D O I：

10.1002/chem.19970030723

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oligo(tetrahydrofurans) (oligo-THFs) 8-12 have been synthesised stereoselectively. Multiple Williamson reactions were used as key steps. While oligo-TWFs with an even number of THF rings like the bi-THFs 8 and 9 as well as the tetra-THFs 10 and 11 were obtained by a bidirectional strategy, the penta-THF 12 with an odd number of THF rings was prepared by a convergent strategy with a sulfone-aldehyde coupling as connecting step, The oligo-THF products are important structural features of natural (Annonaceae acetogenins) and non-natural (artificial inn channels) products.

引用

页码：1170 / 1180

页数：11

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