Infectious complications of immunosuppressive therapy in patients with rheumatic diseases

被引:86
作者
Segal, BH
Sneller, MC
机构
[1] NIAID,IMMUNOREGULAT LAB,NIH,BETHESDA,MD 20892
[2] NIAID,HOST DEF LAB,NIH,BETHESDA,MD 20892
关键词
D O I
10.1016/S0889-857X(05)70327-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Infection continues to be a major cause of morbidity and mortality in patients with rheumatic diseases. The recognition and treatment of infections in these patients is a particularly difficult task because the spectrum of potential pathogens is broad and the clinical manifestations of infection often mimic those of the underlying rheumatic disease. This article presents a general overview of the immunosuppressive properties of agents commonly used in the treatment of rheumatic diseases and focuses on specific pathogens associated with different immunosuppressive regimens. Also provided is a framework for the diagnostic evaluation and treatment of various infectious syndromes in patients with rheumatic diseases.
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页码:219 / &
页数:20
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