Convenient synthesis of C-aza-2,3-dideoxynucleosides

被引：33

作者：

Momotake, A

Togo, H

Yokoyama, M

机构：

[1] Chiba Univ, Fac Sci, Dept Chem, Inage Ku, Chiba 2638522, Japan

[2] Chiba Univ, Grad Sch Sci & Technol, Inage Ku, Chiba 2638522, Japan

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 09期

关键词：

D O I：

10.1039/a900689c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Aryl-1,2,3,4-tetradeoxy-1,4-imino-D-pentitols 5 and 9f are easily synthesized from N-Boc-L-pyroglutamate I ria a successive procedure involving regioselective ring-opening, recyclization with dehydration, stereoselective reduction, and reduction of the ester group. Their structures are determined mainly by X-ray crystallography and NMR measurements. Their bioassay is also described.

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页码：1193 / 1200

页数：8

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