Mechanisms of retroviral recombination

被引:107
作者
Negroni, M
Buc, H
机构
[1] Inst Pasteur, FRE 2364 CNRS, Unite Regulat Enzymat Act Cellulaires, F-75724 Paris 15, France
[2] Inst Pasteur, URA 1960 CNRS, F-75724 Paris 15, France
关键词
strand transfer; reverse transcription; genetic variability; retroviruses; RNA;
D O I
10.1146/annurev.genet.35.102401.090551
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Recombination is a major source of genetic variability in retroviruses. Each viral particle contains two single-stranded genomic RNAs. Recombination mostly results from a switch in template between these two RNAs during reverse transcription. Here we emphasize the main mechanisms underlying recombination that are emerging from recent advances in biochemical and cell culture techniques. Increasing evidence supporting the involvement of RNA secondary structures now complements the predominant role classically attributed to enzyme pausing during reverse transcription. Finally, the implications of recombination on the dynamics of emergence of genomic aberrations in retroviruses are discussed.
引用
收藏
页码:275 / 302
页数:30
相关论文
共 176 条
[1]   CIS elements and trans-acting factors required for minus strand DNA transfer during reverse transcription of the genomic RNA of murine leukemia virus [J].
Allain, B ;
Rascle, JB ;
de Rocquigny, H ;
Roques, B ;
Darlix, JL .
JOURNAL OF MOLECULAR BIOLOGY, 1998, 277 (02) :225-235
[2]   Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia [J].
Allen, TM ;
O'Connor, DH ;
Jing, PC ;
Dzuris, JL ;
Mothé, BR ;
Vogel, TU ;
Dunphy, E ;
Liebl, ME ;
Emerson, C ;
Wilson, N ;
Kunstman, KJ ;
Wang, XC ;
Allison, DB ;
Hughes, AL ;
Desrosiers, RC ;
Altman, JD ;
Wolinsky, SM ;
Sette, A ;
Watkins, DI .
NATURE, 2000, 407 (6802) :386-390
[3]   Retroviral recombination rates do not increase linearly with marker distance and are limited by the size of the recombining subpopulation [J].
Anderson, JA ;
Bowman, EH ;
Hu, WS .
JOURNAL OF VIROLOGY, 1998, 72 (02) :1195-1202
[4]   Testing the hypothesis of a recombinant origin of human immunodeficiency virus type 1 subtype E [J].
Anderson, JP ;
Rodrigo, AG ;
Learn, GH ;
Madan, A ;
Delahunty, C ;
Coon, M ;
Girard, M ;
Osmanov, S ;
Hood, L ;
Mullins, JI .
JOURNAL OF VIROLOGY, 2000, 74 (22) :10752-10765
[5]   Expression of human immunodeficiency virus type 1 reverse transcriptase in trans during virion release and after infection [J].
AnsariLari, MA ;
Gibbs, RA .
JOURNAL OF VIROLOGY, 1996, 70 (06) :3870-3875
[6]  
Arts EJ, 1998, PROG NUCLEIC ACID RE, V58, P339
[7]  
BALAKRISHNAN M, 2001, IN PRESS J BIOL CHEM
[8]   VIRAL RNA-DEPENDENT DNA POLYMERASE - RNA-DEPENDENT DNA POLYMERASE IN VIRIONS OF RNA TUMOUR VIRUSES [J].
BALTIMORE, D .
NATURE, 1970, 226 (5252) :1209-+
[9]   A minor groove binding track in reverse transcriptase [J].
Bebenek, K ;
Beard, WA ;
Darden, TA ;
Li, LP ;
Prasad, R ;
Luxon, BA ;
Gorenstein, DG ;
Wilson, SH ;
Kunkel, TA .
NATURE STRUCTURAL BIOLOGY, 1997, 4 (03) :194-197
[10]  
BENARTZI H, 1993, J BIOL CHEM, V268, P16465