Cycloartane triterpenoids from Astragalus bicuspis

被引：29

作者：

Choudhary, M. Iqbal ^{[1
]}

Jan, Saleem ^{[1
]}

Abbaskhan, Ahmed ^{[1
]}

Musharraf, Syed Ghulam ^{[1
]}

Samreen ^{[1
]}

Sattar, Samina A. ^{[1
]}

Atta-ur-Rahman ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期

关键词：

D O I：

10.1021/np800161j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new cycloartane glycosides have been isolated from Astragalus bicuspis. They were identified as 6 alpha-hydroxy3-O-beta-xylopyranosyloxy-24,25,26,27-tetranor-9,19-cyclolanosta-16,23-lactone (1), 6 alpha-hydroxy-23-methoxy-16 beta,23(R)epoxy-24,25,26,27-tetranor-9,19-cyclolanosta-3-O-beta-xyloside (2), and 23(R),24(S),25(R),26(S)-16 beta/23,23/26,24/25-triepoxy-6 alpha,26-dihydroxy-9,19-cyciolanosta-3-O-beta-xyloside (3), on the basis of their spectroscopic data. Two known cycloartane derivatives, 4 and 5, were also obtained from this plant. Compounds 2-5 were tested for leishmanicidal activity against Leishmania major promastigotes and for cytotoxicity against 3T3 cancer cells.

引用

页码：1557 / 1560

页数：4

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