Two new cyclolanostanol xylosides from the aerial parts of Cimicifuga dahurica

From the aerial parts of Cimicifuga dahurica, two new cyclolanostanol xylosides, cimilactone A (1) and cimilactone B (2), and three known compounds were isolated. On the basis of spectral and chemical evidence, the structures of 1 and 2 were determined to be 12beta-acetoxy-3beta-O-D-xylopyranosyloxy-24,25,26,27-tetranor-9,19-cyclolanost-16,23-lactone (1) and 12beta-acetoxy-3beta-O-D-xylopyranosyloxy-24,25,26,27-tetranor-9,19-cyclolanost-7-ene-16,23-lactone (2). The known compounds were identified as cimigenol 3-O-beta-D-xylopyranoside, 23-O-acetylshengmanol-3-O-beta-D-xylopyranoside, and 25-0-acetylcimigenol-3-O-beta-D-xylopyranoside, respectively.