1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase

被引：42

作者：

Vinh, TK ^{[1
]}

Ahmadi, M ^{[1
]}

Delgado, POL ^{[1
]}

Perez, SF ^{[1
]}

Walters, HM ^{[1
]}

Smith, HJ ^{[1
]}

Nicholls, PJ ^{[1
]}

Simons, C ^{[1
]}

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

enzyme inhibition; P450; aromatase; benzofuran; triazole/tetrazole;

D O I：

10.1016/S0960-894X(99)00328-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using [1 beta-H-3]-androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2105 / 2108

页数：4

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