The transforming growth factor-β superfamily of receptors

被引：348

作者：

de Caestecker, M ^{[1
]}

机构：

[1] Vanderbilt Univ, Div Nephrol, Nashville, TN 37232 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2004年 / 15卷 / 01期

关键词：

TGF-beta; activin; GDF; BMP; receptors; signal transduction; Smads;

D O I：

10.1016/j.cytogfr.2003.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type 1, and type 11 receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The purpose of this review is to describe the biochemical properties of these receptors, focusing specifically on the mechanisms regulating receptor/ligand interactions and activation in mammalian cells. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1 / 11

页数：11

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