6-(4-phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties.

被引：11

作者：

Bisel, P

Gies, JP

Schlewer, G

Wermuth, CG

机构：

[1] FAC PHARM, LAB PHARMACOCHIM MOL, CNRS, UPR 421, F-67401 ILLKIRCH GRAFFENSTADEN, FRANCE

[2] FAC PHARM, LAB NEUROIMMUNOPHARMACOL, INSERM, U425, F-67401 ILLKIRCH GRAFFENSTADEN, FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(96)00562-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly the compound was devoid of the gamma-aminobutyric acid (GABA) uptake inhibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M(1) and M(2) receptors. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3025 / 3028

页数：4

共 19 条

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