6-(4-phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties.

被引:11
作者
Bisel, P
Gies, JP
Schlewer, G
Wermuth, CG
机构
[1] FAC PHARM, LAB PHARMACOCHIM MOL, CNRS, UPR 421, F-67401 ILLKIRCH GRAFFENSTADEN, FRANCE
[2] FAC PHARM, LAB NEUROIMMUNOPHARMACOL, INSERM, U425, F-67401 ILLKIRCH GRAFFENSTADEN, FRANCE
关键词
D O I
10.1016/S0960-894X(96)00562-8
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly the compound was devoid of the gamma-aminobutyric acid (GABA) uptake inhibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M(1) and M(2) receptors. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:3025 / 3028
页数:4
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