Co-detection in the pathogenesis of severe hand-foot-mouth disease

被引：38

作者：

Liu, Li-Juan ^{[1
]}

Xu, Hong-Mei ^{[2
]}

Li, Xiu-Jun ^{[3
]}

Wang, Jun ^{[2
]}

Wang, Xian-Jun ^{[4
]}

Ding, Shu-Jun ^{[4
]}

Tang, Fang ^{[5
]}

Wang, Jing ^{[1
]}

Zhang, Ying-Jie ^{[6
]}

机构：

[1] Chinese Acad Inspect & Quarantine, Inst Hlth Quarantine, Beijing 100123, Peoples R China

[2] Chongqing Med Univ, Childrens Hosp, Dept Diarrhea, Chongqing 400014, Peoples R China

[3] Shandong Univ, Dept Epidemiol & Hlth Stat, Jinan 250012, Peoples R China

[4] Shandong Prov Dis Prevent & Control Ctr, Dept Infect Dis Control, Jinan 250001, Peoples R China

[5] Chinese Peoples Armed Police Forces, Ctr Dis Control & Prevent, Beijing 102613, Peoples R China

[6] Chinese Ctr Dis Control & Prevent, Natl Ctr Publ Hlth Surveillance & Informat Serv, Beijing 102206, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2012年 / 157卷 / 11期

关键词：

Hand-foot-mouth disease; enterovirus; 71; co-detection; ENTEROVIRUS; 71; INFECTION; TAIWAN; CHILDREN; ENCEPHALOPATHY; COMPLICATIONS; OUTBREAK;

D O I：

10.1007/s00705-012-1396-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.

引用

页码：2219 / 2222

页数：4

共 18 条

[1] Neurodevelopment and cognition in children after enterovirus 71 infection
Chang, Luan-Yin
Huang, Li-Min
Gau, Susan Shur-Fen
Wu, Yu-Yu
Hsia, Shao-Hsuan
Fan, Tsui-Yen
Lin, Kuang-Lin
Huang, Yhu-Chering
Lu, Chun-Yi
Lin, Tzou-Yien
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (12) : 1226 - 1234
[2] Rotavirus encephalopathy: Pathogenesis reviewed
Goldwater, PN
Rowland, K
Power, R
Thesinger, M
Abbott, K
Grieve, A
Palombo, EA
Masendycz, PJ
Wilkinson, I
Bear, J
[J]. JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2001, 37 (02) : 206 - 209
[3] An epidemic of enterovirus 71 infection in Taiwan
Ho, MT
Chen, ER
Hsu, KH
Twu, SJ
Chen, KT
Tsai, SF
Wang, JR
Shih, SR
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (13) : 929 - 935
[4] Neurologic complications in children with enterovirus 71 infection
Huang, CC
Liu, CC
Chang, YC
Chen, CY
Wang, ST
Yeh, TF
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (13) : 936 - 942
[5] Norovirus-associated encephalopathy
Ito, Shuichi
Takeshita, Saoko
Nezu, Atsuo
Aihara, Yukoh
Usuku, Shuzo
Noguchi, Yuzo
Yokota, Shumpei
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2006, 25 (07) : 651 - 652
[6] An outbreak of enterovirus 71 infection in Taiwan, 1998: epidemiologic and clinical manifestations
Liu, CC
Tseng, HW
Wang, SM
Wang, JR
Su, IJ
[J]. JOURNAL OF CLINICAL VIROLOGY, 2000, 17 (01) : 23 - 30
[7] Ministry of Health The Executive Yuanm Taiwan ROC, 1998, MMWR-MORBID MORTAL W, V1998, P629
[8] NOROVIRUS ENCEPHALOPATHY IN A PREVIOUSLY HEALTHY CHILD
Obinata, Kaoru
Okumura, Akihisa
Nakazawa, Tomoyuki
Kamata, Ayako
Niizuma, Takahiro
Kinoshita, Keiji
Shimizu, Toshiaki
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2010, 29 (11) : 1057 - 1059
[9] Human enterovirus 71 disease in Sarawak, Malaysia: A prospective clinical, virological, and molecular epidemiological study
Ooi, Mong How
Wong, See Chang
Podin, Yuwana
Akin, Winnie
del Sel, Syvia
Mohan, Anand
Chieng, Chae Hee
Perera, David
Clear, Daniela
Wong, Darin
Blake, Emma
Cardosa, Jane
Solomon, Tom
[J]. CLINICAL INFECTIOUS DISEASES, 2007, 44 (05) : 646 - 656
[10] Qu XW, 2007, EMERG INFECT DIS, V13, P165

← 1 2 →