Functional heavy-chain antibodies in Camelidae

被引:130
作者
Nguyen, VK [1 ]
Desmyter, A [1 ]
Muyldermans, S [1 ]
机构
[1] Free Univ Brussels VIB, B-1050 Brussels, Belgium
来源
ADVANCES IN IMMUNOLOGY, VOL 79 | 2001年 / 79卷
关键词
D O I
10.1016/S0065-2776(01)79006-2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:261 / 296
页数:38
相关论文
共 128 条
[71]  
MURPHY JP, 1989, AM J VET RES, V50, P1279
[72]   SEQUENCE AND STRUCTURE OF V-H DOMAIN FROM NATURALLY-OCCURRING CAMEL HEAVY-CHAIN IMMUNOGLOBULINS LACKING LIGHT-CHAINS [J].
MUYLDERMANS, S ;
ATARHOUCH, T ;
SALDANHA, J ;
BARBOSA, JARG ;
HAMERS, R .
PROTEIN ENGINEERING, 1994, 7 (09) :1129-1135
[73]   Evolution by the birth-and-death process in multigene families of the vertebrate immune system [J].
Nei, M ;
Gu, X ;
Sitnikova, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) :7799-7806
[74]  
Nemazee D, 2000, Adv Immunol, V74, P89
[75]   The specific variable domain of camel heavy-chain antibodies is encoded in the germline [J].
Nguyen, VK ;
Muyldermans, S ;
Hamers, R .
JOURNAL OF MOLECULAR BIOLOGY, 1998, 275 (03) :413-418
[76]  
Nguyen VK, 1999, MOL IMMUNOL, V36, P515, DOI 10.1016/S0161-5890(99)00067-X
[77]   Camel heavy-chain antibodies:: diverse germline VHH and specific mechanisms enlarge the antigen-binding repertoire [J].
Nguyen, VK ;
Hamers, R ;
Wyns, L ;
Muyldermans, S .
EMBO JOURNAL, 2000, 19 (05) :921-930
[78]   Disrupting the hydrophobic patches at the antibody variable/constant domain interface: Improved in vivo folding and physical characterization of an engineered scFv fragment [J].
Nieba, L ;
Honegger, A ;
Krebber, C ;
Pluckthun, A .
PROTEIN ENGINEERING, 1997, 10 (04) :435-444
[79]  
Nisonoff A., 1975, ANTIBODY MOL, V1st
[80]  
NUTALL SD, 2000, CURR PHARM BIOTECHNO, V1, P253