Helicobacter pylori virulence and genetic geography

被引：898

作者：

Covacci, A

Telford, JL

Del Giudice, G

Parsonnet, J

Rappuoli, R

机构：

[1] Chiron SpA, IRIS, I-53100 Siena, Italy

[2] Stanford Univ, Dept Med Infect Dis Hrp T152, Stanford, CA 94305 USA

来源：

SCIENCE | 1999年 / 284卷 / 5418期

关键词：

D O I：

10.1126/science.284.5418.1328

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.

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收藏

页码：1328 / 1333

页数：6

相关论文

共 92 条

[1]

Recombination and clonal groupings within Helicobacter pylori from different geographical regions [J].

Achtman, M ;

Azuma, T ;

Berg, DE ;

Ito, Y ;

Morelli, G ;

Pan, ZJ ;

Suerbaum, S ;

Thompson, SA ;

van der Ende, A ;

van Doorn, LJ .

MOLECULAR MICROBIOLOGY, 1999, 32 (03) :459-470

[2]

Analyses of the cag pathogenicity island of Helicobacter pylori [J].

Akopyants, NS ;

Clifton, SW ;

Kersulyte, D ;

Crabtree, JE ;

Youree, BE ;

Reece, CA ;

Bukanov, NO ;

Drazek, ES ;

Roe, BA ;

Berg, DE .

MOLECULAR MICROBIOLOGY, 1998, 28 (01) :37-53

[3]

Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori [J].

Alm, RA ;

Ling, LSL ;

Moir, DT ;

King, BL ;

Brown, ED ;

Doig, PC ;

Smith, DR ;

Noonan, B ;

Guild, BC ;

deJonge, BL ;

Carmel, G ;

Tummino, PJ ;

Caruso, A ;

Uria-Nickelsen, M ;

Mills, DM ;

Ives, C ;

Gibson, R ;

Merberg, D ;

Mills, SD ;

Jiang, Q ;

Taylor, DE ;

Vovis, GF ;

Trost, TJ .

NATURE, 1999, 397 (6715) :176-180

[4]

The genome sequence of Rickettsia prowazekii and the origin of mitochondria [J].

Andersson, SGE ;

Zomorodipour, A ;

Andersson, JO ;

Sicheritz-Pontén, T ;

Alsmark, UCM ;

Podowski, RM ;

Näslund, AK ;

Eriksson, AS ;

Winkler, HH ;

Kurland, CG .

NATURE, 1998, 396 (6707) :133-140

[5]

The lactosylceramide binding specificity of Helicobacter pylori [J].

Ångström, J ;

Teneberg, S ;

Milh, MA ;

Larsson, T ;

Leonardsson, I ;

Olsson, BM ;

Halvarsson, MÖ ;

Danielsson, D ;

Näslund, I ;

Ljungh, Å ;

Wadström, T ;

Karlsson, KA .

GLYCOBIOLOGY, 1998, 8 (04) :297-309

[6]

[Anonymous], 2010, RUZHYA MIKROBY STALI

[7]

Molecular mimicry between Helicobacter pylori and the host [J].

Appelmelk, BJ ;

Negrini, R ;

Moran, AP ;

Kuipers, EJ .

TRENDS IN MICROBIOLOGY, 1997, 5 (02) :70-73

[8]

Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology [J].

Atherton, JC ;

Tham, KT ;

Peek, RM ;

Cover, TL ;

Blaser, MJ .

JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (03) :552-556

[9]

Inhibition of Helicobacter pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum [J].

Bitzan, MM ;

Gold, BD ;

Philpott, DJ ;

Huesca, M ;

Sherman, PM ;

Karch, H ;

Lissner, R ;

Lingwood, CA ;

Karmali, MA .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (04) :955-961

[10]

PURIFICATION AND CHARACTERIZATION OF AN ALPHA-AMYLASE INHIBITOR FROM MAISE (ZEA-MAIZE) [J].

BLANCOLABRA, A ;

ITURBECHINAS, FA .

JOURNAL OF FOOD BIOCHEMISTRY, 1981, 5 (01) :1-17

← 1 2 3 4 5 6 7 8 9 10 →