A DNA mimic made of non-nucleosidic phenanthrene building blocks

被引：32

作者：

Langenegger, SM ^{[1
]}

Häner, R ^{[1
]}

机构：

[1] Univ Bern, Dept Chem, CH-3012 Bern, Switzerland

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 12期

关键词：

DNA; non-nucleosidic base surrogates; oligonucleoticles; phenanthrene; stacking interactions;

D O I：

10.1002/cbic.200500366

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Figure Presented) Stable stacking. DNA mimics have been prepared from simple, non-nucleosidic building blocks. These oligonucleotides, which contain extended stretches of phenanthrene derivatives, form stable hybrids. The phenanthrene residues contribute to the stability of the duplex through interstrand stacking interactions. The hybrids adopt an overall B-form structure, thus mimicking natural DNA. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2149 / 2152

页数：4

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