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Replacing the nucleohases in DNA with designer molecules

被引：342
作者：
Kool, ET [1 ]
机构：
[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
来源：
ACCOUNTS OF CHEMICAL RESEARCH | 2002年 / 35卷 / 11期
关键词：
D O I：
10.1021/ar000183u
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DNA is not only a carrier of genetic information, but it is also a versatile supramolecular scaffold, arranging smaller organic structures into predesigned geometries. Herein are discussed molecular strategies in which the natural DNA bases on the sugar-phosphate backbone are replaced by other molecules. Some of the base replacements under study include fluorophores, ligands for metals, helix stabilizers, and DNA base shape mimics.
引用
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页码：936 / 943
页数：8
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