Heck, direct arylation, and hydrogenation:: Two or three sequential reactions from a single catalyst

被引:74
作者
Leclerc, JP [1 ]
André, M [1 ]
Fagnou, K [1 ]
机构
[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada
关键词
D O I
10.1021/jo0523619
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Palladium-catalyzed tandem multifunctional reactions leading to the synthesis of substituted biaryl molecules have been developed including tandem Heck-direct arylation and tandem-sequential Heck-direct arylation-hydrogenation. These reactions occur in good yield and have been employed in the synthesis of a cytotoxic biaryl compound.
引用
收藏
页码:1711 / 1714
页数:4
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