Knowing when not to stop: Selenocysteine incorporation in eukaryotes

被引：351

作者：

Low, SC ^{[1
]}

Berry, MJ ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 06期

关键词：

D O I：

10.1016/S0968-0004(96)80016-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of translation frequently involves protein-RNA interactions. An intriguing example of this is the alternative decoding of UGA, typically a stop codon, as selenocysteine. Two RNA structures, the mRNA seleno cysteine insertion sequence (SECIS element) and a unique selenocysteyl-tRNA, are required for this process. In prokaryotes, a single RNA-binding protein, a selenocysteine-specific elongation factor, interacts with both the tRNA and mRNA to confer decoding. Whether eukaryotes use a similar mechanism is currently the subject of intense investigation.

引用

页码：203 / 208

页数：6

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