The prognosis of small primary breast cancers

被引：72

作者：

Kollias, J ^{[1
]}

Murphy, CA ^{[1
]}

Elston, CW ^{[1
]}

Ellis, IO ^{[1
]}

Robertson, JFR ^{[1
]}

Blamey, RW ^{[1
]}

机构：

[1] City Hosp Nottingham, Nottingham, England

来源：

EUROPEAN JOURNAL OF CANCER | 1999年 / 35卷 / 06期

关键词：

breast cancer; size; histological grade; lymph node status; prognosis;

D O I：

10.1016/S0959-8049(99)00056-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Nottingham Prognostic Index (NPI) is an integrated prognostic index used to predict patient survival for women with invasive breast cancer. The index is based on invasive tumour size, histological lymph node stage and tumour grade. The value of such an index has been questioned in small invasive breast cancers and it has been suggested that size is the only necessary prognostic determinant. The aims of this study were to determine the extent of regional lymph node involvement and survival in women with small invasive breast cancers and to assess the value of the NPI. Between 1976 and 1994, 2684 women aged less than or equal to 70 years were treated for primary operable invasive breast cancers of less than or equal to 5 cm in maximum diameter, of which 318 measured less than or equal to 1 cm. Follow-up data were evaluated to determine histological factors important in predicting survival outcomes in women with cancers less than or equal to 1 cm in diameter and comparing their survival according to the NPI with all women treated for primary operable breast cancers less than or equal to 5 cm in maximum diameter. Histological lymph node involvement was demonstrated in 56/318 (18%) of cancers of less than or equal to 1 cm in diameter. Significant survival differences were demonstrated for small breast cancers according to lymph node stage, vascular invasion and histological tumour grade. Only lymph node stage and histological tumour grade were independent prognostic indicators using a multivariate Cox model. The survival curves for small tumours stratified by the NPI were similar to those of cancers up to 5 cm in diameter. The results indicate that lymph node staging and histological grading are still important prognostic determinants for breast cancers less than or equal to 1 cm in diameter. An axillary node staging procedure should be performed for all invasive breast cancers less than or equal to 1 cm in diameter. The NPI remains relevant for small breast cancers. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：908 / 912

页数：5

共 21 条

[11] A PROGNOSTIC INDEX IN PRIMARY BREAST-CANCER [J].