The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

被引：213

作者：

Rask-Andersen, Mathias ^{[1
,2
]}

Masuram, Surendar ^{[1
,2
,3
]}

Schioth, Helgi B. ^{[1
,2
]}

机构：

[1] Uppsala Univ, Dept Neurosci, S-75124 Uppsala, Sweden

[2] Uppsala Univ, Uppsala Biomed Ctr, S-75124 Uppsala, Sweden

[3] Uppsala Monitoring Ctr, S-75140 Uppsala, Sweden

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 54 | 2014年 / 54卷

关键词：

drug targets; clinical trials; kinase; cancer; diabetes; inflammation; DISCOVERY; OPINION; CANCER;

D O I：

10.1146/annurev-pharmtox-011613-135943

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The largest innovations within pharmaceutical development come through new compounds that have unique and novel modes of action. These innovations commonly involve expanding the protein space targeted by pharmaceutical agents. At present, information about drugs and drug targets is available online via public databases such as DrugBank and the Therapeutic Targets Database. However, this information is biased, understandably so, toward established drugs and drug-target interactions. To gain a better overview of the drug-targeted portion of the human proteome and the directions of current drug development, we developed a data set of clinical trial drug-target interactions based on CenterWatch's Drugs in Clinical Trials Database, one of the largest databases of its kind. Our curation identified 475 potentially novel clinical trial drug targets. This review aims to identify trends in drug development based on the potentially novel targets currently being explored in clinical trials.

引用

页码：9 / 26

页数：18

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