Mass spectrometric analysis of cross-linking sites for the structure of proteins and protein complexes

被引：64

作者：

Lee, Young Jin ^{[1
]}

机构：

[1] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

来源：

MOLECULAR BIOSYSTEMS | 2008年 / 4卷 / 08期

关键词：

D O I：

10.1039/b801810c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mass spectrometry has become the method of choice to detect and quantify the minute amounts of proteins at the genomic scale. It has recently been adopted for three dimensional structure analyses of proteins or protein complexes by chemically cross-linking their intact forms and analyzing the cross-linked pieces after digestion. This highlight provides an overview of the technology with a focus on advances in the last two years. This cross-linking mass spectrometry has a great potential to become a powerful tool to supplement current X-ray and NMR method of protein structure analysis.

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收藏

页码：816 / 823

页数：8

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