Transcription factor AP-1, and the role of Fra-2

被引:92
作者
Foletta, VC
机构
[1] Div. of Immunology and Cell Biology, John Curtin Sch. of Medical Research, Australian National University, Canberra, ACT
[2] Div. of Immunology and Cell Biology, John Curtin Sch. of Medical Research, Australian National University, Canberra
关键词
fos genes; fos-related antigens; gene expression regulation; immediate-early genes; jun genes; transcription factor AP-1; transcription factors; SERUM RESPONSE ELEMENT; C-FOS EXPRESSION; TISSUE-SPECIFIC EXPRESSION; DNA-BINDING ACTIVITY; RNA POLYMERASE-II; PROTEIN-KINASE-C; SIGNAL-TRANSDUCTION PATHWAYS; IMMEDIATE-EARLY GENE; TRANSGENIC MICE; GROWTH-FACTORS;
D O I
10.1038/icb.1996.17
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Transcription factors function to regulate gene transcription. They may be constitutively expressed or may only be activated during specific situations. Activator protein-1 (AP-I) is an inducible transcription factor, and is comprised of multiple protein complexes that include the gene products of the fos and jun gene families. Numerous cellular and viral genes contain AP-1 binding sites within their promoters and, accordingly, AP-I has been shown to play a role in the regulation of both basal and inducible transcription of these genes. fos-related antigen-2 (fra-2) has been found to have both similar and unique properties to that of other fos gene members in terms of its regulation and expression. The analysis and determination of the function of Fra-2 will provide further information on the role of AP-1.
引用
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页码:121 / 133
页数:13
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