Cephalosporin-3′-diazeniumdiolates: Targeted NO-Donor Prodrugs for Dispersing Bacterial Biofilms

被引：125

作者：

Barraud, Nicolas ^{[2
,3
]}

Kardak, Bharat G. ^{[1
]}

Yepuri, Nageshwar R. ^{[1
]}

Howlin, Robert P. ^{[5
,6
,7
]}

Webb, Jeremy S. ^{[5
,6
,7
]}

Faust, Saul N. ^{[5
,6
,8
,9
]}

Kjelleberg, Staffan ^{[2
,3
,4
]}

Rice, Scott A. ^{[2
,3
,4
]}

Kelso, Michael J. ^{[1
]}

机构：

[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia

[2] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[3] Univ New S Wales, Ctr Marine Bioinnovat, Sydney, NSW 2052, Australia

[4] Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore, Singapore

[5] Univ Southampton, NIHR Resp Biomed Res Unit, Southampton SO9 5NH, Hants, England

[6] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England

[7] Univ Southampton, Ctr Biol Sci, Southampton SO9 5NH, Hants, England

[8] Univ Southampton, NIHR Wellcome Trust Clin Res Facil, Southampton SO9 5NH, Hants, England

[9] Southampton Univ Hosp, NHS Fdn Trust, Southampton, Hants, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 36期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

antibiotics; biofilms; cephalosporins; nitric oxide; prodrugs; NITRIC-OXIDE DONORS; PSEUDOMONAS-AERUGINOSA; AGENTS; INFECTIONS; HYDROLYSIS;

D O I：

10.1002/anie.201202414

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Just say NO to biofilms: NO-donors are used to disperse a bacterial biofilm so that co-administered antibiotics will kill the more susceptible unattached cells. The chemically stable cephalosporin-3'-diazeniumdiolate NO-donor prodrug (see scheme) is activated by bacterial β-lactamases and facilitates this two-step biofilm erradication. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9057 / 9060

页数：4

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