共 61 条
Gamma oscillations mediate stimulus competition and attentional selection in a cortical network model
被引:120
作者:
Borgers, Christoph
[1
]
Epstein, Steven
[2
,3
]
Kopell, Nancy J.
[2
,3
]
机构:
[1] Tufts Univ, Dept Math, Medford, MA 02155 USA
[2] Boston Univ, Dept Math, Boston, MA 02215 USA
[3] Boston Univ, Ctr Biodynam, Boston, MA 02215 USA
来源:
基金:
美国国家卫生研究院;
美国国家科学基金会;
关键词:
cholinergic modulation;
selective attention;
gamma rhythm;
D O I:
10.1073/pnas.0809511105
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Simultaneous presentation of multiple stimuli can reduce the firing rates of neurons in extrastriate visual cortex below the rate elicited by a single preferred stimulus. We describe computational results suggesting how this remarkable effect may arise from strong excitatory drive to a substantial local population of fast-spiking inhibitory interneurons, which can lead to a loss of coherence in that population and thereby raise the effectiveness of inhibition. We propose that in attentional states fast-spiking interneurons may be subject to a bath of inhibition resulting from cholinergic activation of a second class of inhibitory interneurons, restoring conditions needed for gamma rhythmicity. Oscillations and coherence are emergent features, not assumptions, in our model. The gamma oscillations in turn support stimulus competition. The mechanism is a form of "oscillatory selection," in which neural interactions change phase relationships that regulate firing rates, and attention shapes those neural interactions.
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页码:18023 / 18028
页数:6
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