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Vitamin C: Antioxidant or pro-oxidant in vivo?

被引：409
作者：
Halliwell, B
机构：
[1] Neurodegenerative Disease Res Centre, Pharmacology Group, King's College, University of London, London SW3 6LX, Manresa Road
来源：
FREE RADICAL RESEARCH | 1996年 / 25卷 / 05期
关键词：
ascorbate; iron; copper; antioxidant; haemochromatosis;
D O I：
10.3109/10715769609149066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ascorbic acid has a multiplicity of antioxidant properties, but it can exert pro-oxidant effects in vitro, usually by interaction with transition metal ions. It is as yet uncertain that these pro-oxidant effects have any biological relevance: some of the available data are summarized.
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页码：439 / 454
页数：16
相关论文
共 181 条
  • [1] MUTAGENICITY OF ASCORBIC-ACID FOR THE PLANT ARABIDOPSIS
    ACEDO, GN
    REDEI, GP
    SANDHU, SS
    [J]. MUTATION RESEARCH, 1984, 129 (01): : 57 - 62
  • [2] FREE RADICAL-INDUCED FRAGMENTATION OF PROTEINS BY QUERCETIN
    AHMED, MS
    AINLEY, K
    PARISH, JH
    HADI, SM
    [J]. CARCINOGENESIS, 1994, 15 (08) : 1627 - 1630
  • [3] SERUM NON-TRANSFERRIN-BOUND IRON IN BETA-THALASSEMIA MAJOR PATIENTS TREATED WITH DESFERRIOXAMINE AND L1
    ALREFAIE, FN
    WICKENS, DG
    WONKE, B
    KONTOGHIORGHES, GJ
    HOFFBRAND, AV
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1992, 82 (02) : 431 - 436
  • [4] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING
    AMES, BN
    SHIGENAGA, MK
    HAGEN, TM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) : 7915 - 7922
  • [5] A COMPILATION OF SPECIFIC BIMOLECULAR RATE CONSTANTS FOR REACTIONS OF HYDRATED ELECTRONS HYDROGEN ATOMS AND HYDROXYL RADICALS WITH INORGANIC AND ORGANIC COMPOUNDS IN AQUEOUS SOLUTION
    ANBAR, M
    NETA, P
    [J]. INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1967, 18 (07): : 493 - &
  • [6] ASCORBATE-INDUCED FREE-RADICAL TOXICITY TO ISOLATED ISLET CELLS
    ANDERSSON, M
    GRANKVIST, K
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1995, 27 (05) : 493 - 498
  • [7] IRON OVERLOAD AUGMENTS THE DEVELOPMENT OF ATHEROSCLEROTIC LESIONS IN RABBITS
    ARAUJO, JA
    ROMANO, EL
    BRITO, BE
    PARTHE, V
    ROMANO, M
    BRACHO, M
    MONTANO, RF
    CARDIER, J
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (08) : 1172 - 1180
  • [8] INACTIVATION OF ALPHA-ANTIPROTEINASE BY HYDROXYL RADICALS - THE EFFECT OF URIC-ACID
    ARUOMA, OI
    HALLIWELL, B
    [J]. FEBS LETTERS, 1989, 244 (01): : 76 - 80
  • [9] COPPER-ION-DEPENDENT DAMAGE TO THE BASES IN DNA IN THE PRESENCE OF HYDROGEN-PEROXIDE
    ARUOMA, OI
    HALLIWELL, B
    GAJEWSKI, E
    DIZDAROGLU, M
    [J]. BIOCHEMICAL JOURNAL, 1991, 273 : 601 - 604
  • [10] ASMUS KD, 1987, RADIOPROTECTORS ANTI, P23
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