Severe lactic acidosis induced by nucleoside analogues in an HIV-infected man

被引：24

作者：

Roy, PM ^{[1
]}

Gouello, JP ^{[1
]}

Pennison-Besnier, I ^{[1
]}

Chennebault, JM ^{[1
]}

机构：

[1] Univ Hosp, Dept Emergency Med, Angers, France

来源：

ANNALS OF EMERGENCY MEDICINE | 1999年 / 34卷 / 02期

关键词：

D O I：

10.1016/S0196-0644(99)70244-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Nucleoside analogues can induce myopathy or hepatitis by means of mitochondrial dysfunction. We report the case of a 31-year-old man infected with HIV who had a severe lactic acidosis without muscle or liver symptoms. He improved after hemodialysis and withdrawal of antiviral drugs. Muscle and liver evaluation allowed us to ascribe lactic acidosis to a mitochondriopathy induced by zidovudine and didanosine.

引用

页码：282 / 284

页数：3