Second-trimester pregnancy loss is associated with activated protein C resistance

被引：132

作者：

Rai, R

Regan, L

Hadley, E

Dave, M

Cohen, H

机构：

[1] ST MARYS HOSP,DEPT HAEMATOL,LONDON W2 1NY,ENGLAND

[2] ST MARYS HOSP,DEPT OBSTET & GYNAECOL,LONDON W2 1NY,ENGLAND

[3] UNIV LONDON SCH MED,LONDON,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1996年 / 92卷 / 02期

关键词：

activated protein C resistance; pregnancy; miscarriage;

D O I：

10.1046/j.1365-2141.0000.d01-1465.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have investigated whether activated protein C resistance (APCR) is associated with second-trimester miscarriage. The prevalence of APCR was significantly higher amongst women with a history of second-trimester miscarriage (10/50; 20%) compared with either women with a history of first-trimester miscarriages only (4/70; 5.7%) or a control group of parous women with no previous history of pregnancy losses (3/70; 4.3%) (P < 0.02). These results suggest that APCR may be an important mechanism of second-trimester pregnancy loss, possibly related to the increase in intravascular coagulation that occurs during pregnancy.

引用

页码：489 / 490

页数：2

共 11 条

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