Not just research tools - proteasome inhibitors offer therapeutic promise

被引：88

作者：

Goldberg, AL ^{[1
]}

Rock, K

机构：

[1] Harvard Med Sch, Dept Cell Biol, Boston, MA 02138 USA

[2] Univ Massachusetts, Med Ctr, Dept Pathol, Worcester, MA USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 04期

关键词：

D O I：

10.1038/nm0402-338

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteasome inhibitors have served as critical tools to investigate protein degradation in eukaryotic cells. Now, these inhibitors are proving effective in the treatment of cancer and inflammatory disorders, most recently in animal models of psoriasis.

引用

页码：338 / 340

页数：3

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