14-3-3 proteins: A historic overview

被引：692

作者：

Aitken, Alastair ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

SEMINARS IN CANCER BIOLOGY | 2006年 / 16卷 / 03期

基金：

英国惠康基金;

关键词：

14-3-3; proteins; history; phospho-binding motifs; protein interactions; protein kinases;

D O I：

10.1016/j.semcancer.2006.03.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the differences between potentially cancer-relevant isoforms on the genomic, protein and functional level. The focus will therefore be on mammalian 14-3-3s although many important developments in the field have involved Drosophila 14-3-3 proteins for example and the cross-fertilisation from parallel studies on plant 14-3-3 should not be underestimated. In the major part of this review I will attempt to focus on some novel data and aspects of 14-3-3 structure and function, in particular regulation of 14-3-3 isoforms by oncogene-related protein kinase phosphorylation and aspects of 14-3-3 research with which newcomers to the field may be less familiar. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：162 / 172

页数：11

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