Widespread intra-serotype recombination in natural populations of dengue virus

被引：176

作者：

Worobey, M ^{[1
]}

Rambaut, A ^{[1
]}

Holmes, EC ^{[1
]}

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1999年 / 96卷 / 13期

基金：

英国惠康基金;

关键词：

D O I：

10.1073/pnas.96.13.7352

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diversity analysis of 71 published dengue virus gene sequences revealed several strains that appeared to be mosaics comprising gene regions with conflicting evolutionary histories. Subsequent maximum likelihood breakpoint estimation identified seven recombinants, including members of three of the four dengue virus serotypes. with breakpoints in the premembrane/membrane gene, the envelope gene, and at the junction of the envelope and first nonstructural genes. Many of the individual recombinants contain sequence representing separate genetic subtypes. The results were highly statistically significant and were confirmed by phylogenetic analysis of the regions of interest. These findings indicate that recombination may play a very significant role in shaping genetic diversity in dengue virus and, as such, have important implications for its biology and its control.

引用

页码：7352 / 7357

页数：6

共 23 条

[11]

HALSTEAD SB, 1988, SCIENCE, V239, P476, DOI 10.1126/science.3277268

[12] Phylogenetic evidence for recombination in dengue virus [J].