Wearable Electrochemical Sensors and Biosensors: A Review

被引:517
作者
Windmiller, Joshua Ray [1 ]
Wang, Joseph [1 ]
机构
[1] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA
基金
美国国家科学基金会;
关键词
Wearable sensors; Screen-printed electrodes; Textiles; Fabrics; Intelligent clothing; Flexible devices; Body sensor networks; Epidermal monitoring; SCREEN-PRINTED ELECTRODES; HEALTH-CARE; TEXTILE SENSORS; GLUCOSE; STRAIN; CIRCUITS; SYSTEM; PERFORMANCE; TYROSINASE; DESIGN;
D O I
10.1002/elan.201200349
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This article reviews recent advances and developments in the field of wearable sensors with emphasis on a subclass of these devices that are able to perform highly-sensitive electrochemical analysis. Recent insights into novel fabrication methodologies and electrochemical techniques have resulted in the demonstration of chemical sensors able to augment conventional physical measurements (i.e. heart rate, EEG, ECG, etc.), thereby providing added dimensions of rich, analytical information to the wearer in a timely manner. Wearable electrochemical sensors have been integrated onto both textile materials and directly on the epidermis for various monitoring applications owing to their unique ability to process chemical analytes in a non-invasive and non-obtrusive fashion. In this manner, multi-analyte detection can easily be performed, in real time, in order to ascertain the overall physiological health of the wearer or to identify potential offenders in their environment. Of profound importance is the development of an understanding of the impact of mechanical strain on textile- and epidermal (tattoo)-based sensors and their failure mechanisms as well as the compatibility of the substrate employed in the fabrication process. We conclude this review with a retrospective outlook of the field and identify potential implications of this new sensing paradigm in the healthcare, fitness, security, and environmental monitoring domains. With continued innovation and detailed attention to core challenges, it is expected that wearable electrochemical sensors will play a pivotal role in the emergent body sensor networks arena.
引用
收藏
页码:29 / 46
页数:18
相关论文
共 86 条
[1]   Flexible technologies and smart clothing for citizen medicine, home healthcare, and disease prevention [J].
Axisa, F ;
Schmitt, PM ;
Gehin, C ;
Delhomme, G ;
McAdams, E ;
Dittmar, A .
IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE, 2005, 9 (03) :325-336
[2]   Low cost flex substrates for miniaturized electronic assemblies [J].
Barlow, F ;
Lostetter, A ;
Elshabini, A .
MICROELECTRONICS RELIABILITY, 2002, 42 (07) :1091-1099
[3]   The development and characterisation of conducting polymeric-based sensing devices. [J].
Brady, S ;
Lau, KT ;
Megill, W ;
Wallace, GG ;
Diamond, D .
SYNTHETIC METALS, 2005, 154 (1-3) :25-28
[4]   Flexible thick-film electrochemical sensors: Impact of mechanical bending and stress on the electrochemical behavior [J].
Cai, Jiaying ;
Cizek, Karel ;
Long, Brenton ;
McAferty, Kenyon ;
Campbell, Casey G. ;
Allee, David R. ;
Vogt, Bryan D. ;
La Belle, Jeff ;
Wang, Joseph .
SENSORS AND ACTUATORS B-CHEMICAL, 2009, 137 (01) :379-385
[5]   Oligonucleotide-modified screen-printed gold electrodes for enzyme-amplified sensing of nucleic acids [J].
Carpini, G ;
Lucarelli, F ;
Marrazza, G ;
Mascini, M .
BIOSENSORS & BIOELECTRONICS, 2004, 20 (02) :167-175
[6]   Towards the integration of textile sensors in a wireless monitoring suit [J].
Catrysse, M ;
Puers, R ;
Hertleer, C ;
Van Langenhove, L ;
van Egmond, H ;
Matthys, D .
SENSORS AND ACTUATORS A-PHYSICAL, 2004, 114 (2-3) :302-311
[7]   Development of an Electrochemical Immunoassay Based on the Use of an Eight-Electrodes Screen-Printed Array Coupled with Magnetic Beads for the Detection of Antimicrobial Sulfonamides in Honey [J].
Centi, S. ;
Stoica, A. I. ;
Laschi, S. ;
Mascini, M. .
ELECTROANALYSIS, 2010, 22 (16) :1881-1888
[8]  
Cerny M, 2008, IFMBE PROC, V20, P194
[9]  
Chang C. H., 2007, ENG MED BIOL SOC ANN, V4, P121
[10]   An analytical model of strain isolation for stretchable and flexible electronics [J].
Cheng, H. ;
Wu, J. ;
Li, M. ;
Kim, D. -H. ;
Kim, Y. -S. ;
Huang, Y. ;
Kang, Z. ;
Hwang, K. C. ;
Rogers, J. A. .
APPLIED PHYSICS LETTERS, 2011, 98 (06)