Organelle-targeted nanocarriers: Specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo

被引：166

作者：

Boddapati, Sarathi V. ^{[1
]}

D'Souza, Gerard G. M. ^{[1
]}

Erdogan, Suna ^{[1
]}

Torchilin, Vladimir P. ^{[1
]}

Weissig, Volkmar ^{[1
]}

机构：

[1] Northeastern Univ, Bouve Coll Hlth Sci, Dept Pharmaceut Sci, Boston, MA 02115 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 08期

关键词：

D O I：

10.1021/nl801908y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To further increase the therapeutic activity of drugs known to act on intracellular target sites, in vivo drug delivery approaches must actively mediate the specific delivery of drug molecules to the subcellular site of action. We show here that surface modification of nanocarriers with mitochondriotropic triphenylphosphonium cations facilitates the efficient subcellular delivery of a model drug to mitochondria of mammalian cells and improves its activity in vitro and in vivo.

引用

页码：2559 / 2563

页数：5

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