Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines

被引：130

作者：

Ransohoff, RM

机构：

[1] Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Mellen Ctr MS Treatment & Res, Cleveland, OH 44195 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1999年 / 98卷 / 01期

关键词：

adhesion molecules; CNS; leukocyte; chemokines;

D O I：

10.1016/S0165-5728(99)00082-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Molecular mechanisms of inflammatory leukocyte accumulation in the central nervous system (CNS) have been addressed during the past fifteen years, using small-animal model systems. Identification of the molecules responsible for leukocyte-endothelial adherence, and the elucidation of the roles of chemokines, has promoted further understanding. These insights have become clinically relevant, as attested by ongoing and contemplated multiple sclerosis (MS) treatment trials. (C) 1999 Elsevier Science B.V. All rights reserved.

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收藏

页码：57 / 68

页数：12

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