How do microRNAs regulate gene expression?

被引：297

作者：

Cannell, Ian G. ^{[1
]}

Kong, Yi Wen ^{[1
]}

Bushell, Martin ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharm, Ctr Biomol Sci, Nottingham NG7 2RD, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

gene expression; in vitro-transcribed RNA; microRNA (miRNA); polysomes; protein synthesis; translation;

D O I：

10.1042/BST0361224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3'-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational silencing. The exact mechanism of miRNA-mediated translational repression is yet to be fully determined, but recent data from our laboratory have shown that the stage of translation which is inhibited by miRNAs is dependent upon the promoter used for transcribing the target mRNA. This review focuses on understanding how miRNA repression is operating in light of these findings and the questions that still remain.

引用

页码：1224 / 1231

页数：8

共 48 条

[1] [Anonymous], 2007, SCI SINGAL, DOI DOI 10.1126/STKE.3672007RE1
[2] Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
Bagga, S
Bracht, J
Hunter, S
Massirer, K
Holtz, J
Eachus, R
Pasquinelli, AE
[J]. CELL, 2005, 122 (04) : 553 - 563
[3] Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies
Barbee, Scott A.
Estes, Patricia S.
Cziko, Anne-Marie
Hillebrand, Jens
Luedeman, Rene A.
Coller, Jeff M.
Johnson, Nick
Howlett, Iris C.
Geng, Cuiyun
Ueda, Ryu
Brand, Andrea H.
Newbury, Sarah F.
Wilhelm, James E.
Levine, Richard B.
Nakamura, Akira
Parker, Roy
Ramaswami, Mani
[J]. NEURON, 2006, 52 (06) : 997 - 1009
[4] MRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes
Behm-Ansmant, Isabelle
Rehwinkel, Jan
Doerks, Tobias
Stark, Alexander
Bork, Peer
Izaurralde, Elisa
[J]. GENES & DEVELOPMENT, 2006, 20 (14) : 1885 - 1898
[5] Relief of microRNA-mediated translational repression in human cells subjected to stress
Bhattacharyya, Suvendra N.
Habermacher, Regula
Martine, Ursula
Closs, Ellen I.
Filipowicz, Witold
[J]. CELL, 2006, 125 (06) : 1111 - 1124
[6] DISSOCIATION OF MAMMALIAN POLYRIBOSOMES INTO SUBUNITS BY PUROMYCIN
BLOBEL, G
SABATINI, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (02) : 390 - &
[7] Chendrimada TP, 2007, NATURE, V447, P823, DOI 10.1038/nature05841
[8] Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54
Chu, Chia-ying
Rana, Tariq M.
[J]. PLOS BIOLOGY, 2006, 4 (07) : 1122 - 1136
[9] Global control of gene expression in yeast by the Ccr4-Not complex
Collart, MA
[J]. GENE, 2003, 313 : 1 - 16
[10] Specificity of microRNA target selection in translational repression
Doench, JG
Sharp, PA
[J]. GENES & DEVELOPMENT, 2004, 18 (05) : 504 - 511

← 1 2 3 4 5 →