How do microRNAs regulate gene expression?

被引：297

作者：

Cannell, Ian G. ^{[1
]}

Kong, Yi Wen ^{[1
]}

Bushell, Martin ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharm, Ctr Biomol Sci, Nottingham NG7 2RD, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

gene expression; in vitro-transcribed RNA; microRNA (miRNA); polysomes; protein synthesis; translation;

D O I：

10.1042/BST0361224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3'-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational silencing. The exact mechanism of miRNA-mediated translational repression is yet to be fully determined, but recent data from our laboratory have shown that the stage of translation which is inhibited by miRNAs is dependent upon the promoter used for transcribing the target mRNA. This review focuses on understanding how miRNA repression is operating in light of these findings and the questions that still remain.

引用

页码：1224 / 1231

页数：8

共 48 条

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