Solid-phase synthesis and 1H and 13C high-resolution magic angle spinning NMR of 13C-labeled resin-bound saccharides

被引：8

作者：

Loening, NM ^{[1
]}

Kanemitsu, T ^{[1
]}

Seeberger, PH ^{[1
]}

Griffin, RG ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2004年 / 42卷 / 05期

关键词：

NMR; H-1; C-13; oligosaccharides; high-resolution magic angle spinning; solid support; gel phase; carbohydrates;

D O I：

10.1002/mrc.1364

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We show how high-resolution magic angle-spinning NMR spectroscopy can be used to characterize C-13-labeled saccharides that have been prepared using solid-phase synthesis techniques while they are still bound to a solid-support resin. With the use of C-13-labeled glucose as the starting material, we have successfully synthesized mono-, di- and trisaccharides with uniform C-13 labeling of the saccharide rings. Using these materials, we have been able to assign the C-13 and H-1 spectra and to characterize various impurities on the resin beads. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：453 / 458

页数：6

共 23 条

[1]

[Anonymous], 2001, SOLID SUPPORT OLIGOS

[2] NATURAL ABUNDANCE C-13-C-13 COUPLING OBSERVED VIA DOUBLE-QUANTUM COHERENCE [J].