Predictors of major hemorrhage following fibrinolysis for acute pulmonary embolism

被引：116

作者：

Fiumara, K

Kucher, N

Fanikos, J

Goldhaber, SZ ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pharm, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Div Cardiovasc, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2006年 / 97卷 / 01期

关键词：

D O I：

10.1016/j.amjcard.2005.07.117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One hundred four patients at Brigham and Women's Hospital who received alteplase for acute pulmonary embolism were evaluated. Major bleeding occurred in 20 patients (19.2%). The principal site of bleeding was unknown in 9 (45.0%), gastrointestinal in 6 (30.0%), retroperitoneal in 3 (15.0%), intracranial in 1 (5.0%). and splenic in 1 (5.0%). Independent predictors of major hemorrhage were the administration of catecholamines for systemic arterial hypotension (odds ratio [OR] 115, 95% confidence interval [CI] 9.4 to 1,410.9, p <0.001), cancer (OR 16.0, 95% CI 3.2 to 80, p = 0.004), diabetes mellitus (OR 9.6, 95% CI 1.7 to 54, p = 0.010), and elevated international normalized ratio before fibrinolysis (OR 5.8, 95% CI 1.5 to 22, p = 0.012). (c) 2006 Elsevier Inc. All rights reserved.

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页码：127 / 129

页数：3

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