Novel polyamide based nucleic acid analogs - Synthesis of oligomers and RNA-binding properties

The synthesis of never polyamide based nucleic acid analogs incorporating monomer units of type I - III has been accomplished using solid-phase strategies based on N-delta-Fmoc protected building blocks. An oligomer composed of monomer units I exhibited weak, but sequence-specific RNA binding. Improved RNA-binding affinity was observed for analogs incorporating building blocks of type III with 2-(R) stereochemistry, but nor in the case of the 2-(S) isomers. (C) 1997 Elsevier Science Ltd.