Effect of flavonoids on cell cycle progression in prostate cancer cells

被引：186

作者：

Kobayashi, T

Nakata, T

Kuzumaki, T ^{[1
]}

机构：

[1] Yamagata Univ, Sch Med, Dept Biochem, Yamagata 9909585, Japan

[2] Yamagata Univ, Sch Med, Dept Urol, Yamagata 9909585, Japan

来源：

CANCER LETTERS | 2002年 / 176卷 / 01期

关键词：

genistein; apigenin; luteolin; cyclin; cell cycle; prostate;

D O I：

10.1016/S0304-3835(01)00738-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of some flavonoids, which are components of fruits, vegetables, and peas, on the cell cycle progression of human LNCaP prostate cancer cells has been investigated in this study. Genistein arrested the cell cycle at the G2/M phases, which is attributed to the suppression of cyclin B expression. In addition, genistein induced the cyclin-dependent kinase inhibitor p21, which does not depend on p53 activation. Apigenin and luteolin also increased p21 levels, but quercetin did not. Apigenin induced p21 production through a p53-dependent pathway, but luteolin did so in a p53-independent manner. These results suggest that flavonoids are potent regulators of cyclin B and p21 for cell cycle progression, which may play some roles in prevention of carcinogenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：17 / 23

页数：7

共 36 条

[1] P53 CONTROLS BOTH THE G(2)/M AND THE G(1) CELL-CYCLE CHECKPOINTS AND MEDIATES REVERSIBLE GROWTH ARREST IN HUMAN FIBROBLASTS [J].