学术探索
学术期刊
新闻热点
数据分析
智能评审

Sonic hedgehog in the nervous system: functions, modifications and mechanisms

被引：117
作者：
Ho, KS
Scott, MP
机构：
[1] Stanford Univ, Sch Med, Dept Dev Biol, Howard Hughes Med Inst,Beckman Ctr B300, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Dev Biol, Dept Genet, Stanford, CA 94305 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0959-4388(02)00290-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Signaling by Sonic hedgehog (Shh) controls important developmental processes, including dorsoventral neural tube patterning, neural stem cell proliferation, and neuronal and glial cell survival. Shh signaling involves lipid modifications to Shh itself, as well as changes in protein subcellular localization. Recent advances have revealed the importance of palmitoylation and acylation of Shh on its potency and migration capacity. Subsequent trafficking and organelle sorting in the Shh signaling pathway have been observed; these observations offer a new dimension to our understanding of downstream signal transduction events.
引用
收藏
页码：57 / 63
页数：7
相关论文
共 61 条
  • [21] Regulated endocytic routing modulates wingless signaling in Drosophila embryos
    Dubois, L
    Lecourtois, M
    Alexandre, C
    Hirst, E
    Vincent, JP
    [J]. CELL, 2001, 105 (05) : 613 - 624
  • [22] Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene
    Eggenschwiler, JT
    Anderson, KV
    [J]. DEVELOPMENTAL BIOLOGY, 2000, 227 (02) : 648 - 660
  • [23] Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
    Eggenschwiler, JT
    Espinoza, E
    Anderson, KV
    [J]. NATURE, 2001, 412 (6843) : 194 - 198
  • [24] Gradient formation of the TGF-β homolog Dpp
    Entchev, EV
    Schwabedissen, A
    González-Gaitán, M
    [J]. CELL, 2000, 103 (06) : 981 - 991
  • [25] Pax6 controls progenitor cell identity and neuronal fate in response to graded shh signaling
    Ericson, J
    Rashbass, P
    Schedl, A
    BrennerMorton, S
    Kawakami, A
    vanHeyningen, V
    Jessell, TM
    Briscoe, J
    [J]. CELL, 1997, 90 (01) : 169 - 180
  • [26] Tbx1, a DiGeorge syndrome candidate gene, is regulated by Sonic hedgehog during pharyngeal arch development
    Garg, V
    Yamagishi, C
    Hu, TH
    Kathiriya, IS
    Yamagishi, H
    Srivastava, D
    [J]. DEVELOPMENTAL BIOLOGY, 2001, 235 (01) : 62 - 73
  • [27] Altered neural cell fates and medulloblastoma in mouse patched mutants
    Goodrich, LV
    Milenkovic, L
    Higgins, KM
    Scott, MP
    [J]. SCIENCE, 1997, 277 (5329) : 1109 - 1113
  • [28] Argosomes: A potential vehicle for the spread of morphogens through epithelia
    Greco, V
    Hannus, M
    Eaton, S
    [J]. CELL, 2001, 106 (05) : 633 - 645
  • [29] The whereabouts of a morphogen: Direct evidence for short- and graded long-range activity of hedgehog signaling peptides
    Gritli-Linde, A
    Lewis, P
    McMahon, AP
    Linde, A
    [J]. DEVELOPMENTAL BIOLOGY, 2001, 236 (02) : 364 - 386
  • [30] Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain
    Huang, Z
    Kunes, S
    [J]. CELL, 1996, 86 (03) : 411 - 422
1234567