Immunogenetics of Spontaneous Control of HIV

被引：77

作者：

Carrington, Mary ^{[1
,2
]}

Walker, Bruce D. ^{[2
]}

机构：

[1] NCI Frederick, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD 20882 USA

[2] Ragon Inst MGH MIT & Harvard, Boston, MA 02114 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 63 | 2012年 / 63卷

关键词：

HLA-B; HLA-C 3 ' UTR; genome-wide association study; cytotoxic T lymphocytes; microRNA; IMMUNODEFICIENCY-VIRUS TYPE-1; MAJOR HISTOCOMPATIBILITY COMPLEX; CELL-SURFACE EXPRESSION; CYTOTOXIC T-LYMPHOCYTES; HLA-C EXPRESSION; CLASS-I; HOMOSEXUAL-MEN; MESSENGER-RNA; DISEASE PROGRESSION; HEAVY-CHAIN;

D O I：

10.1146/annurev-med-062909-130018

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Host genetic variation is presently estimated to account for about one-fourth of the observed differences in control of HIV across infected individuals. Genome-wide association studies have confirmed that polymorphism within the HLA class I locus is the primary host genetic contributor to determining outcome after infection. Here we progress beyond the genetic associations alone to consider the functional explanations for these correlations. In this process, the complex and multidimensional effects of HLA molecules in viral disease become apparent.

引用

页码：131 / 145

页数：15

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