Isolation and structures of haterumalides NA, NB, NC, ND, and NE, novel macrolides from an Okinawan sponge Ircinia sp.

被引：74

作者：

Takada, N ^{[1
]}

Sato, H

Suenaga, K

Arimoto, H

Yamada, K

Ueda, K

Uemura, D

机构：

[1] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] Shizuoka Univ, Fac Sci, Dept Chem, Shizuoka 4228529, Japan

[3] Sagami Chem Res Ctr, Sagamihara, Kanagawa 2290012, Japan

[4] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(99)01291-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel macrolides, haterumalides NA (1), NB (2), NC (3), ND (4), and NE (5), were isolated from an Okinawan sponge Ircinia sp. The absolute stereostructure of 1 was determined by spectroscopic analysis and modified Mosher's method. Haterumalide NA (1) showed cytotoxicity against P388 cells and acute toxicity against mice. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6309 / 6312

页数：4

共 5 条

[1] Pinnaic acid and tauropinnaic acid: Two novel fatty acids composing a 6-Azaspiro[4.5]decane unit from the Okinawan bivalve Pinna muricata [J].