Synthesis of novel ring-substituted histidines and histamines

被引：22

作者：

Jain, R

Cohen, LA

King, MM

机构：

[1] NIDDK,NIH,BIOORGAN CHEM LAB,BETHESDA,MD 20892

[2] GEORGE WASHINGTON UNIV,DEPT CHEM,WASHINGTON,DC 20052

来源：

TETRAHEDRON | 1997年 / 53卷 / 13期

关键词：

D O I：

10.1016/S0040-4020(97)00177-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of novel 2-cycloalkyl-L-histidines and 2-cycloalkylhistamines via radical alkylation with cycloalkylcarboxylic acids and silver nitrate in the presence of 10% H2SO4 by ammonium persulfate is described The method is also extended to the synthesis of 1,2-dialkyl-L-histidines and 1,2-dialkylhistamines. (C) 1997 Elsevier Science Ltd.

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收藏

页码：4539 / 4548

页数：10

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