TALENoffer: genome-wide TALEN off-target prediction

被引：69

作者：

Grau, Jan ^{[1
]}

Boch, Jens ^{[2
]}

Posch, Stefan ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Comp Sci, D-06099 Halle, Saale, Germany

[2] Univ Halle Wittenberg, Dept Genet, Inst Biol, D-06099 Halle, Saale, Germany

来源：

BIOINFORMATICS | 2013年 / 29卷 / 22期

关键词：

D O I：

10.1093/bioinformatics/btt501

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targeted mutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALEN off-targets. We show that TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning complete mammalian genomes within a few minutes.

引用

页码：2931 / 2932

页数：2

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