Evaluation of the mutagenic and antimutagenic effects of South African plants

被引：87

作者：

Reid, K. A.

Maes, J.

Maes, A.

van Staden, J.

De Kimpe, N.

Mulholland, D. A.

Verschaeve, L.

机构：

[1] Univ KwaZulu Natal, Sch Biol & Conservat Sci, Res Ctr Plant Growth & Dev, ZA-3209 Pietermaritzburg, South Africa

[2] Flemish Inst Technol Res Vito, Expertise Ctr Environm Toxicol, B-2400 Mol, Belgium

[3] Univ Ghent, Dept Organ Chem, Fac Biosci Engn, B-9000 Ghent, Belgium

[4] Univ KwaZulu Natal Durban, Sch Chem, Nat Prod Res Grp, ZA-4041 Durban, South Africa

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 106卷 / 01期

关键词：

ames test; mutagenicity; antimutagenicity; traditional medicinal plants;

D O I：

10.1016/j.jep.2005.11.030

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Dichloromethane and 90% methanol extracts of 42 South African plants were screened for mutagenicity and antimutagenicity using the Salmonella/microsome mutagenicity assay (Ames) against Salmonella typhimurium TA98 and TA100 bacterial strains in the presence and absence of metabolic activator S9. The methanol extracts from whole plants of Helichrysum simillimum, Helichrysum herbaceum and Helichrysum rugulosum indicated mutagenicity. These are the first reported tests on the mutagenicity of Helichrysum species. Six species indicated antimutagenic properties, all in the presence of S9: methanol leaf extract of Bauhinia galpinii, and dichloromethane leaf extracts of Bauhinia galpinii, Clerodendrum myricoides, Datura stramonium, Buddleja saligna, Millettia sutherlandii and Sutherlandia frutescens. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：44 / 50

页数：7

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