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The immune contexture in human tumours: impact on clinical outcome

被引：3608
作者：
Fridman, Wolf Herman [1 ,2 ,3 ,4 ]
Pages, Franck [1 ,3 ,4 ,5 ]
Sautes-Fridman, Catherine [1 ,2 ,3 ]
Galon, Jerome [1 ,3 ,4 ,5 ]
机构：
[1] Univ Paris 06, Cordeliers Res Ctr, F-75006 Paris, France
[2] INSERM, Lab Immune Microenvironm & Tumours, UMRS872, F-75006 Paris, France
[3] Univ Paris 05, Cordeliers Res Ctr, F-75006 Paris, France
[4] Georges Pompidou European Hosp, AP HP, F-75015 Paris, France
[5] INSERM, Lab Integrat Canc Immunol, UMRS872, F-75006 Paris, France
来源：
NATURE REVIEWS CANCER | 2012年 / 12卷 / 04期
关键词：
REGULATORY T-CELLS; NATURAL-KILLER-CELLS; INDEPENDENT PROGNOSTIC-FACTOR; PREDICTS IMPROVED SURVIVAL; VERTICAL GROWTH-PHASE; LONG-TERM SURVIVAL; INFILTRATING LYMPHOCYTES; COLORECTAL-CANCER; HEPATOCELLULAR-CARCINOMA; FAVORABLE PROGNOSIS;
D O I：
10.1038/nrc3245
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.
引用
收藏
页码：298 / 306
页数：9
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